It was the second time the business was targeted in the space of three months, police say, after a previous armed robbery allegedly saw two people threatened before drugs were taken.

Police were called to a pharmacy in the main street of Griffith on Tuesday morning after reports of an armed robbery.

According to police, a man entered the Banna Avenue shop and pulled out a firearm, then ordered staff to the floor.

He allegedly then made off with a large quantity of prescription medication.

A 22-year-old Goolgowi man was arrested at a Noorebar Avenue, Griffith address soon after investigations began, police said.

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He was taken to Griffith police station and charged with two counts of armed robbery and two of possessing a prohibited drug.

Police allege he was involved in a second armed robbery at the same premises on June 23.

The man was refused bail and is due to appear in Griffith Local Court on Wednesday.