During Missing Person's Week, which runs until Sunday, Griffith Detective Inspector Paul Smith has renewed calls for new leads.

Linda Humphries disappeared from Fitzroy Falls, near Nowra, on or around October 31, 1975 at the age of 21 and her body has never been found.

She had been married for four weeks when she disappeared.

An inquest earlier this year was inconclusive.

"She pretty much disappeared without a trace and then some bones were found. We have some remains we believe are hers," Detective Inspector Smith said.

"It went to inquest in early 2014 and the state coroner, after hearing all the evidence, made an open finding. In essence, the matter is still an open case, however, we're no further than we were before."

Detective Inspector Smith said there were a number of possibilities that were considered, including self harm. He said Linda's family attended the inquest.

An inquest into the disappearance of Michael Chandler, who was last seen on March 8, 1973, has also been conducted.

The coroner also delivered an open finding, leaving the matter open.

"This is quite a strange one," Detective Inspector Smith said.

"He picked up his pay and is apparently gone never to be seen again. However, a family member believes they saw him at traffic lights 15 years later."

Detective Inspector said police would like to be able to give the families of these two missing persons some answers.

"We don't know if he up and left of his own accord and started a new life or whether he might have met with foul play," Detective Inspector Smith said.

"People can wish to start a new life, not wish to be in the environment they're in, however, we encourage them to let someone know they're OK. While they are reported as a missing person to police there is someone who is worried about their safety and there is a police investigation going attempting to locate them."

Detective Inspector Smith urged anyone with information to come forward.

"People may think the information they have is worthless, however it might be the key we are looking for or it might be corroborating some similar information we've had that makes us look in a particular area or follow up a particular line of inquiry," he said.

People can provide information to Crime Stoppers anonymously.

Anyone with information can contact Griffith police on 6969 4299 or Crime Stoppers on 1800 333 000.