The 15th annual Griffith Toy Run will kick off at 8.30am on Saturday with bikies young and old, tough and not-so-tough, congregating to raise money for Can Assist.

Headed by Locky Miller, who devised the fund-raiser with a group of mates 15 years ago, the toy run will require all participants to bring along a donation for Can Assist or a toy.

Mr Miller hopes to gather at least as many entrants as last year when 150 people joined the ride.

"The smallest we've had was 85 people and I think the biggest was 283," Mr Miller said.

The 2.5-hour "mystery ride" will take road-bike riders on a 150-kilometre loop, while dirt bike riders can enjoy a scenic journey through Cocoparra National Park.

All riders will eventually return to the Yenda Hotel for a barbecue lunch.

"It's open to any sort of bikes but also hotrods and custom cars," Mr Miller said.

"Quite often we have people come along in cars because they don't have a bike but want to be part of the day."

First-time toy runner Jamie Piva has a brand new dirt bike and is looking forward to meeting other riders.

"A lot of people with bikes don't know any other people with bikes," Mr Miller said.

"This is a great opportunity for them to come along and get together and get to know other people."

Can Assist will use the toy donations to make hampers for sick local kids and will donate any extras to St Vincent de Paul to distribute in time for Christmas.