Sydney Roosters flyer Roger Tuivasa-Sheck is no chance to play on Friday night after fronting at training on Thursday in a moon boot.
Tuivasa-Sheck injured his ankle in the Roosters' last-start loss to the Titans. Shaun Kenny-Dowall will play on the wing in his place against a South Sydney side expected to be unchanged.
Will Matthews is likely to drop off the Dragons bench when they host the New Zealand Warriors on Saturday afternoon.
The Titans' casualty ward continues to grow with co-captain Nate Myles struggling with a damaged ankle as Gold Coast prepare for their do-or-die clash against Melbourne. Mark Ioane is on standby for Myles.
The Cowboys and Tigers should be 1-17 as the Cowboys look to cement their place in the top eight with a win against the joint-venture club in Townsville on Saturday night.
Manly will be missing Brett Stewart, Anthony Watmough, Jorge Taufua and Jamie Buhrer when they host Penrith.
Neville Costigan may spend some time at hooker as Newcastle deal with the loss of Craig Gower (neck) and Kurt Gidley (ankle) in their game against Parramatta. The Eels will be without Jarryd Hayne.
A hamstring injury is again expected to keep Cronulla five-eighth Todd Carney sidelined. Carney twinged his hamstring in the lead-up to Cronulla's last-start loss to North Queensland.
Chad Townsend is Carney's likely replacement with Wade Graham sidelined to play Canberra in the last regular-season match of the season. Graham and Jayson Bukuya have been rested as they battle niggling injuries.